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The mechanism stopping DNA replication inspires cancer research

The mechanism stopping DNA replication inspires cancer research

NTU discovers how cell stabilizes its division through terminating telomere replication, inspires cancer research Glossary : Telomere a region of sequences protecting the end of the chromosome and stabilizing cells Telomerase synthesizes telomeres CDKs, Aurora and Polo-like kinases major regulatory molecules coordinating cell division Phosphorylation a metabolic process in the cell cycle, triggering the action of telomeres Protein phosphatase 2A (PP2A) a special protein in the de-phospho...

Fasting Blood Sugar and Risk of Pancreatic Cancer

Fasting Blood Sugar and Risk of Pancreatic Cancer

Elevated Fasting Blood Sugar is Associated with Increased Risk of Pancreatic Cancer Even in the Prediabetic Range Pancreatic adenocarcinoma is a most lethal cancer with increasing incidence rate in recent years. Previous epidemiologic studies had linked type 2 diabetes to pancreatic adenocarcinoma, but studies examining the association between blood glucose and pancreatic cancer yielded, however, inconsistent results. In light of this, Dr. Wei-Chih Liao, an attending physician at the NTU hosp...

New discovery inspiring severe cancer pain treatment

New discovery inspiring severe cancer pain treatment

NTU discovered why the cancer pain-killer medicine is decreasing its function, inspiring new drug development In clinical practice, patients’ tolerance towards pain-killer opioid medicines is always a tough issue. Especially for severe cancer patients, to sooth their severe cancer pain, the long-term, increase, use of opioid pain-killer, however, inevitably leads to the decrease of its efficacy. In order to improve the quality of clinical treatment, and to investigate the physiological react...

Invasion

Invasion

Unraveling the mechanism behind invasive yeast growth In energy depleted environments, cells will be stimulated to migrate toward nutritional or carbonic sources, and in some cases, may even turn invasive. Why is this so? Many fungi will switch to filamentous growth in order to search for nutrition in energy depleted environments. The filamentous growth is considered invasive, and is associated with Arf3p in yeast, which is the homologue of mammalian Arf6. ADP-ribosylation factors ...

Genetic mystery behind lung cancer

Genetic mystery behind lung cancer

YAP1 mutation is a germline risk allele for lung adenocarcinoma According to the statistics from Ministry of Health and Welfare in Taiwan, lung cancer is the leading cause of death among malignancies. Among non-smokers, lung adenocarcinoma is the predominant histologic type. However, lacking obvious symptoms and smoking history, early diagnosis is of great difficulty. As early symptoms are vague, genetic factors may be another guide for screening. Compared with heredity factors in man...

Life after cancer

Life after cancer

Quality of life changes after treatment for hepatocellular carcinoma Most primary liver cancers are classified as hepatocellular carcinoma (HCC), which is also the second leading cause of cancer-related death worldwide, responsible for about 600000 deaths annually. The incidence of HCC varies among different regions, which is particularly high in East Asia and Sub-Saharan Africa. Besides, the incidence is more than twice as high in males as in females. According to the statistics from Ministr...

Criegee intermediate

Criegee intermediate

The simplest Criegee intermediate can react very rapidly with water vapor, and the reaction kinetics demonstrates a quadratic rate dependence on the concentration of water molecules, which indicates that two water molecules are required to react with one Criegee intermediate. This research result demystified the reaction kinetics between Criegee intermediate and water vapor, and thereupon has calmed academic disputes and caught the attention of international community in atmosphe...

World-unique coral pyramids

World-unique coral pyramids

Geosciences researchers prove Micronesia’s coral pyramidal tombs much older than previous thoughts Monumental tombs within ancient civilizations worldwide hold precious clues for deciphering the architectural skill, acumen, and industry of prehistoric cultures. A recent study has found that the world’s only coral pyramidal tombs, which are located in Kosrae, Micronesia, dated back to 700 years ago by Prof. Chuan-Chou Shen of the High-Precision Mass Spectrometry and Environment Change Laborato...

To Stop or not to Stop

To Stop or not to Stop

Unraveling the mystery of continuous and discontinuous transcription of coronaviruses In the past, human coronaviruses are common pathogens for mild upper respiratory tract infection. However, in recent years, new coronavirus pandemics, including severe acute respiratory syndrome (SRAS) and Middle East respiratory syndrome (MERS), claimed many lives with high mortality rates. As coronavirus pandemics pose an increasing threat in human society, drug development is an urgent issue. Before di...

Single allergen-induced oral tolerance inhibits airway inflammation in conjugated allergen immunized mice

Single allergen-induced oral tolerance inhibits airway inflammation in conjugated allergen immunized mice

The immune system tolerates to the protein through the oral routes and this phenomenon is called oral tolerance. The underlying mechanism of oral tolerance is sophisticated and has been studied for decades. Many patients have allergy to the house dust mites and which have more than 20 groups of allergens. Therefore, we tried to investigate the effect of oral tolerance induced by single protein on the animals had allergy to 2 or more proteins. The mice were sensitized with the conjugated protei...